Article
ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function.
Nature communications - 4 Jan 2021
Zhou Qiling, Yu Miao, Tirado-Magallanes Roberto, Li Bin, Kong Lingshi, Guo Mingrui, Tan Zi Hui, Lee Sanghoon, Chai Li, Numata Akihiko, Benoukraf Touati, Fullwood Melissa Jane, Osato Motomi, Ren Bing, Tenen Daniel G
Abstract excerpt
CCCTC binding factor (CTCF) is an important factor in the maintenance of chromatin-chromatin interactions, yet the mechanism regulating its binding to chromatin is unknown. We demonstrate that zinc finger protein 143 (ZNF143) is a key regulator for CTCF-bound promoter-enhancer loops. In the murine genome, a large percentage of CTCF and ZNF143 DNA binding motifs are distributed 37 bp apart in the convergent...
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