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Article

Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage

1 Jan 2021

Abstract excerpt

In early pregnancy, the placenta anchors the conceptus and supports embryonic development and survival. This study aimed to investigate the underlying functions of Shh signaling in recurrent miscarriage (RM), a serious disorder of pregnancy. In the present study, Shh and Gli2 were mainly observed in cytotrophoblasts (CTBs), Ptch was mainly observed in syncytiotrophoblasts (STBs), and Smo and Gli3 were expressed...

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PMID: 33390589
DOI: 10.1038/s12276-020-00530-6

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