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Article

Molecular basis of androgen insensitivity syndromes.

Molecular and cellular endocrinology - 1 Mar 2021

Hornig Nadine C, Holterhus Paul-Martin

Abstract excerpt

Individuals with complete androgen insensitivity syndrome show a female genital phenotype despite 46, XY gonosomes and the presence of androgen producing testes. This clinical observation indicates the resistance of the body and its cells to androgens like testosterone. At the molecular level, this hormone resistance is caused by hemizygous loss of function mutations in the X-chromosomal androgen receptor (AR)...

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Identifiers

PMID: 33385475
DOI: 10.1016/j.mce.2020.111146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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