The p53 signaling pathway of the large yellow croaker ( Larimichthys crocea ) responds to acute cold stress: evidence via spatiotemporal expression analysis of p53 , p21 , MDM2 , IGF-1 , Gadd45 , Fas , and Akt

Abstract excerpt

The p53 activation is induced by stressors, such as DNA damage, oxidative stress, and activated oncogenes, and can promote cell cycle arrest, cellular senescence, and apoptosis. The large yellow croaker ( Larimichthys crocea ) is an important warm temperate marine fish in the Chinese aquiculture industry. However, few studies have investigated the role of p53 in the response of L . crocea to environmental...

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