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Article

Analysis of copy number variation in dogs implicates genomic structural variation in the development of anterior cruciate ligament rupture.

PloS one - 1 Jan 2020

Binversie Emily E, Baker Lauren A, Engelman Corinne D, Hao Zhengling, Moran John J, Piazza Alexander M, Sample Susannah J, Muir Peter

Abstract excerpt

Anterior cruciate ligament (ACL) rupture is an important condition of the human knee. Second ruptures are common and societal costs are substantial. Canine cranial cruciate ligament (CCL) rupture closely models the human disease. CCL rupture is common in the Labrador Retriever (5.79% prevalence), ~100-fold more prevalent than in humans. Labrador Retriever CCL rupture is a polygenic complex disease, based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33382735
DOI: 10.1371/journal.pone.0244075
PMCID: PMC7774950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of copy number variation in dogs implicates genomic structural variation in the development of anterior cruciate ligament rupture.PMID 33382735Read ↗

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