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Article

Multivariate genome-wide association analysis identifies novel and relevant variants associated with anterior cruciate ligament rupture risk in the dog model.

BMC genetics - 26 Jun 2018

Baker Lauren A, Rosa Guilherme J M, Hao Zhengling, Piazza Alexander, Hoffman Christopher, Binversie Emily E, Sample Susannah J, Muir Peter

Abstract excerpt

BACKGROUND: Anterior cruciate ligament rupture (ACLR) is a debilitating and potentially life-changing condition in humans, as there is a high prevalence of early-onset osteoarthritis after injury. Identification of high-risk individuals before they become patients is important, as post-treatment lifetime burden of ACLR in the USA ranges from $7.6 to $17.7 billion annually. ACLR is a complex disease with multiple...

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Identifiers

PMID: 29940858
DOI: 10.1186/s12863-018-0626-7
PMCID: PMC6019516

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DOCK2
ROR2

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