Article
Mixed cytomegalovirus genotypes in HIV-positive mothers show compartmentalization and distinct patterns of transmission to infants.
eLife - 31 Dec 2020
Pang Juanita, Slyker Jennifer A, Roy Sunando, Bryant Josephine, Atkinson Claire, Cudini Juliana, Farquhar Carey, Griffiths Paul, Kiarie James, Morfopoulou Sofia, Roxby Alison C, Tutil Helena, Williams Rachel, Gantt Soren, Goldstein Richard A, Breuer Judith
Abstract excerpt
Cytomegalovirus (CMV) is the commonest cause of congenital infection and particularly so among infants born to HIV-infected women. Studies of congenital CMV infection (cCMVi) pathogenesis are complicated by the presence of multiple infecting maternal CMV strains, especially in HIV-positive women, and the large, recombinant CMV genome. Using newly developed tools to reconstruct CMV haplotypes, we demonstrate...
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