Article
[6S]-5-Methyltetrahydrofolic Acid and Folic Acid Pregnancy Diets Differentially Program Metabolic Phenotype and Hypothalamic Gene Expression of Wistar Rat Dams Post-Birth.
Nutrients - 25 Dec 2020
Pannia Emanuela, Hammoud Rola, Simonian Rebecca, Arning Erland, Ashcraft Paula, Wasek Brandi, Bottiglieri Teodoro, Pausova Zdenka, Kubant Ruslan, Anderson G Harvey
Abstract excerpt
[6S]-5-methyltetrahydrofolic acid (MTHF) is a proposed replacement for folic acid (FA) in diets and prenatal supplements. This study compared the effects of these two forms on maternal metabolism and hypothalamic gene expression. Pregnant Wistar rats received an AIN-93G diet with recommended FA (1X, 2 mg/kg, control), 5X-FA or equimolar levels of MTHF. During lactation they received the control diet and then a...
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