Article
The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations.
Cancer immunology, immunotherapy : CII - 1 Jun 2021
Willvonseder Barbara, Stögbauer Fabian, Steiger Katja, Jesinghaus Moritz, Kuhn Peer-Hendrik, Brambs Christine, Engel Jutta, Bronger Holger, Schmidt Georg Philipp, Haller Bernhard, Weichert Wilko, Keller Gisela, Noske Aurelia, Pfarr Nicole, Boxberg Melanie
Abstract excerpt
OBJECTIVE: POLE-mutant, microsatellite-instable (MSI), p53-mutant and non-specific molecular profile (NSMP) are TCGA-defined molecular subgroups of endometrial cancer (EC). Hypothesizing that morphology and tumor immunology might differ depending on molecular background concerning composition and prognostic impact, we aimed to comprehensively interconnect morphologic, immunologic and molecular data. METHODS:...
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