Article
The Neoantigen Landscape of Mycosis Fungoides.
Frontiers in immunology - 1 Jan 2020
Sivanand Arunima, Hennessey Dylan, Iyer Aishwarya, O'Keefe Sandra, Surmanowicz Philip, Vaid Gauravi, Xiao Zixuan, Gniadecki Robert
Abstract excerpt
Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma, for which there is no cure. Immune checkpoint inhibitors have been tried in MF but the results have been inconsistent. To gain insight into the immunogenicity of MF we characterized the neoantigen landscape of this lymphoma, focusing on the known predictors of responses to immunotherapy: the quantity, HLA-binding strength and...
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