Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin‐6 maintains bone marrow‐derived mesenchymal stem cell stemness by an ERK1/2‐dependent mechanism

31 Jul 2009

Abstract excerpt

Adult human mesenchymal stem cells (MSCs) hold promise for an increasing list of therapeutic uses due to their ease of isolation, expansion, and multi-lineage differentiation potential. To maximize the clinical potential of MSCs, the underlying mechanisms by which MSC functionality is controlled must be understood. We have taken a deconstructive approach to understand the individual components in vitro, namely...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesenchymal stem cell research
Share to Osteoarthritis Treatment and Mechanisms
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19650110
DOI: 10.1002/jcb.22289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin‐6 maintains bone marrow‐derived mesenchymal stem cell stemness by an ERK1/2‐dependent mechanismPMID 19650110Read ↗

Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative MedicineSemantic proximity Read ↗

Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferationSemantic proximity Read ↗

TNF-Stimulated Gene-6 Is a Key Regulator in Switching Stemness and Biological Properties of Mesenchymal Stem CellsSemantic proximity Read ↗

Interleukin‐6 induces the lineage commitment of bone marrow‐derived mesenchymal multipotent cells through down‐regulation of Sox2 by osteogenic transcription factorsSemantic proximity Read ↗

Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapySemantic proximity Read ↗

Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cellsSemantic proximity Read ↗

Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells.Semantic proximity Read ↗

Biochemical Heterogeneity of Mesenchymal Stem Cell Populations: Clues to their Therapeutic EfficacySemantic proximity Read ↗

Comparative Transcriptomics Identifies Potential Stemness-Related Markers for Mesenchymal Stromal/Stem CellsSemantic proximity Read ↗

PDGF, TGF-β, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineagesSemantic proximity Read ↗

The Function and Regulation of BMP6 in Various Kinds of Stem CellsSemantic proximity Read ↗

Mesenchymal Stem Cells in Tissue RepairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.