Article
Relation of α2-Antiplasmin Genotype and Genetic Determinants of Fibrinogen Synthesis and Fibrin Clot Formation with Vascular Endothelial Growth Factor Level in Axial Spondyloarthritis.
International journal of molecular sciences - 9 Dec 2020
Hoppe Berthold, Schwedler Christian, Haibel Hildrun, Verba Maryna, Proft Fabian, Protopopov Mikhail, Heuft Hans-Gert, Rios Rodriguez Valeria, Edelmann Anke, Rudwaleit Martin, Sieper Joachim, Poddubnyy Denis
Abstract excerpt
OBJECTIVE: Coagulation and fibrinolysis are interrelated with the expression of vascular endothelial growth factor (VEGF), which frequently is increased in axial spondyloarthritis (axSpA). We tested whether (i) α2-antiplasmin (A2AP) Arg6Trp, (ii) fibrinogen, factor XIII A-subunit or B-subunit genotypes are associated with VEGF levels and assessed whether the known association between elevated VEGF and...
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