Elucidation of molecular pathogenesis and drug development for psychiatric disorders from rare disease-susceptibility variants.

Abstract excerpt

Recent rapid progress in genome analysis and large-scale consortia has made it possible to discover variants with a variety of allele frequencies and effect sizes associated with psychiatric disorders. Among psychiatric disorder-susceptibility variants, rare variants with large effect sizes detected by sequencing analysis or array comparative genomic hybridization would be particularly useful for elucidating...

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