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Phylogenetic Analysis of SARS-CoV-2 Data Is Difficult.

Molecular biology and evolution - 4 May 2021

Morel Benoit, Barbera Pierre, Czech Lucas, Bettisworth Ben, Hübner Lukas, Lutteropp Sarah, Serdari Dora, Kostaki Evangelia-Georgia, Mamais Ioannis, Kozlov Alexey M, Pavlidis Pavlos, Paraskevis Dimitrios, Stamatakis Alexandros

Abstract excerpt

Numerous studies covering some aspects of SARS-CoV-2 data analyses are being published on a daily basis, including a regularly updated phylogeny on nextstrain.org. Here, we review the difficulties of inferring reliable phylogenies by example of a data snapshot comprising a quality-filtered subset of 8,736 out of all 16,453 virus sequences available on May 5, 2020 from gisaid.org. We find that it is difficult to...

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Identifiers

PMID: 33316067
DOI: 10.1093/molbev/msaa314
PMCID: PMC7798910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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