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Article

Adoptive transfer of placental ischemia-stimulated natural killer cells causes a preeclampsia-like phenotype in pregnant rats.

American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Jun 2021

Travis Olivia K, Baik Cedar, Tardo Geilda A, Amaral Lorena, Jackson Carmilya, Greer Mallory, Giachelli Chelsea, Ibrahim Tarek, Herrock Owen T, Williams Jan M, Cornelius Denise C

Abstract excerpt

PROBLEM: The Reduced Uterine Perfusion Pressure (RUPP) rat model of placental ischemia recapitulates many characteristics of preeclampsia including maternal hypertension, intrauterine growth restriction (IUGR), and increased cytolytic natural killer cells (cNKs). While we have previously shown a 5-fold higher cytotoxicity of RUPP NKs versus normal pregnant NKs, their role in RUPP pathophysiology remains unclear....

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Identifiers

PMID: 33315281
DOI: 10.1111/aji.13386
PMCID: PMC8131208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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