Article
Drug repurposing using transcriptome sequencing and virtual drug screening in a patient with glioblastoma.
Investigational new drugs - 1 Jun 2021
Saeed Mohamed E M, Kadioglu Onat, Greten Henry Johannes, Yildirim Adem, Mayr Katharina, Wenz Frederik, Giordano Frank A, Efferth Thomas
Abstract excerpt
Background Precision medicine and drug repurposing are attractive strategies, especially for tumors with worse prognosis. Glioblastoma is a highly malignant brain tumor with limited treatment options and short survival times. We identified novel BRAF (47-438del) and PIK3R1 (G376R) mutations in a glioblastoma patient by RNA-sequencing. Methods The protein expression of BRAF and PIK3R1 as well as the lack of EGFR...
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