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High repetitive arginine in the anterior of PCV3 capsid protein is a severe obstacle for its expression in E. coli

1 Dec 2020

Abstract excerpt

Porcine circovirus type 3 (PCV3) is a novel circovirus identified in sows with PDNS-like clinical signs and reproductive failure. The capsid protein (CAP) of PCV3 is expected to be an effective vaccine candidate. Here, we expressed the original capsid protein, truncated capsid protein without anterior highly repetitive arginine (ΔCAP) and their codon-optimized counterparts in E. coli. These results showed that...

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PMID: 33306160
DOI: 10.1186/s13568-020-01163-8

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