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Article

CADM1 promotes malignant features of small-cell lung cancer by recruiting 4.1R to the plasma membrane.

Biochemical and biophysical research communications - 1 Jan 2021

Funaki Toko, Ito Takeshi, Tanei Zen-Ichi, Goto Akiteru, Niki Toshiro, Matsubara Daisuke, Murakami Yoshinori

Abstract excerpt

Cell adhesion molecule 1 (CADM1), which mediates intercellular adhesion between epithelial cells, is shown to be highly expressed in small-cell lung cancer (SCLC) and to enhance tumorigenicity of SCLC cells in nude mice. Here, we investigated the molecular mechanism underlying the oncogenic role of CADM1 in SCLC. CADM1 promoted colony formation of SCLC cells in soft agar. Analysis of deletion and point mutants of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33298314
DOI: 10.1016/j.bbrc.2020.11.121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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