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Article

Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma.

Scientific reports - 8 Dec 2020

Rakhsh-Khorshid Hassan, Samimi Hilda, Torabi Shukoofeh, Sajjadi-Jazi Sayed Mahmoud, Samadi Hamed, Ghafouri Fatemeh, Asgari Yazdan, Haghpanah Vahid

Abstract excerpt

Anaplastic thyroid carcinoma (ATC) is the most rare and lethal form of thyroid cancer and requires effective treatment. Efforts have been made to restore sodium-iodide symporter (NIS) expression in ATC cells where it has been downregulated, yet without complete success. Systems biology approaches have been used to simplify complex biological networks. Here, we attempt to find more suitable targets in order to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33293661
DOI: 10.1038/s41598-020-78574-x
PMCID: PMC7722919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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