Single-cell RNA sequencing of equine mesenchymal stromal cells from primary donor-matched tissue sources reveals functional heterogeneity in immune modulation and cell motility

Abstract excerpt

BACKGROUND: The efficacy of mesenchymal stromal cell (MSC) therapy is thought to depend on the intrinsic heterogeneity of MSC cultures isolated from different tissue sources as well as individual MSCs isolated from the same tissue source, neither of which is well understood. To study this, we used MSC cultures isolated from horses. The horse is recognized as a physiologically relevant large animal model...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mesenchymal stem cell research
• Share to Pluripotent Stem Cells Research
• Share to Single-cell and spatial transcriptomics