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Single-cell RNA-seq highlights heterogeneity in human primary Wharton’s jelly mesenchymal stem/stromal cells cultured in vitro

6 Apr 2020

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Abstract Background Mesenchymal stem/stromal cells (MSCs) are multipotent cells with a promising application potential in regenerative medicine and immunomodulation. However, MSCs cultured in vitro exhibit functional heterogeneity. The underlying molecular mechanisms that define MSC heterogeneity remain unclear. Methods We investigated the gene expression profile via single-cell RNA sequencing (scRNA-seq) of...

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PMID: 32252818
DOI: 10.1186/s13287-020-01660-4

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