Article
Subtype Diagnosis of Sporadic Creutzfeldt-Jakob Disease with Diffusion Magnetic Resonance Imaging.
Annals of neurology - 1 Mar 2021
Bizzi Alberto, Pascuzzo Riccardo, Blevins Janis, Moscatelli Marco E M, Grisoli Marina, Lodi Raffaele, Doniselli Fabio M, Castelli Gianmarco, Cohen Mark L, Stamm Aymeric, Schonberger Lawrence B, Appleby Brian S, Gambetti Pierluigi
Abstract excerpt
OBJECTIVE: Sporadic Creutzfeldt-Jakob disease (sCJD) comprises several subtypes as defined by genetic and prion protein characteristics, which are associated with distinct clinical and pathological phenotypes. To date, no clinical test can reliably diagnose the subtype. We established two procedures for the antemortem diagnosis of sCJD subtype using diffusion magnetic resonance imaging (MRI). METHODS: MRI of...
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