Article
Hepatitis C virus genotype 4 resistance and subtype demographic characterization of patients treated with ombitasvir plus paritaprevir/ritonavir.
Antimicrobial agents and chemotherapy - 1 Nov 2015
Schnell Gretja, Tripathi Rakesh, Beyer Jill, Reisch Thomas, Krishnan Preethi, Lu Liangjun, Dekhtyar Tatyana, Hall Coleen, Vilchez Regis A, Pilot-Matias Tami, Collins Christine
Abstract excerpt
Hepatitis C virus (HCV) genotype 4 (GT4) is genetically diverse, with 17 confirmed subtypes, and comprises approximately 13% of infections worldwide. In this study, we identified GT4 subtypes by phylogenetic analysis, assessed differences in patient demographics across GT4 subtypes, examined baseline sequence variability among subtypes and the potential impact on treatment outcome, and analyzed the development of...
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