Article
Small Molecule T315 Promotes Casitas B-Lineage Lymphoma-Dependent Degradation of Epidermal Growth Factor Receptor via Y1045 Autophosphorylation.
American journal of respiratory and critical care medicine - 1 Apr 2016
Huang Kuo-Yen, Kao Shih-Han, Wang Wen-Lung, Chen Chi-Yuan, Hsiao Tzu-Hung, Salunke Santosh B, Chen Jeremy J W, Su Kang-Yi, Yang Shuenn-Chen, Hong Tse-Ming, Chen Ching-Shih, Yang Pan-Chyr
Abstract excerpt
RATIONALE: Despite the fact that tyrosine kinase inhibitors (TKIs) have been found effective in treating patients harboring activating mutations of epidermal growth factor receptor (EGFR), an acquired secondary mutation, T790M, which lowers the affinity to TKIs, can lead to EGFR TKI resistance after this standard treatment. OBJECTIVES: To evaluate the effect of small molecule T315 on EGFR degradation and its...
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