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Article

TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma.

Technology in cancer research & treatment - 1 Jan 2000

Sun Jing, Yu Xijiao, Xue Lande, Li Shu, Li Jianxia, Tong Dongdong, Du Yi

Abstract excerpt

TP53 mutations are the most occurred mutation in HNSCC which might affect the ion channel genes. We aim to investigate the ion channel gene alteration under TP53 mutation and their prognostic implication. The overall mutation status of HNSCC were explored. By screening the TP53-associated ion channel genes (TICGs), an ion channel prognostic signature (ICPS) was established through a series of machine learning...

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Identifiers

PMID: 33243093
DOI: 10.1177/1533033820972344
PMCID: PMC7705194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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