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Article

Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis.

Proteins - 1 Dec 2014

Xu Tingting, Xu Jinxin, Ye Yinghua, Wang Qi, Shu Xiaodong, Pei Duanqing, Liu Jinsong

Abstract excerpt

Sorting nexin 10 (SNX10), the unique member of the SNX family having vacuolation activity in cells, was shown to be involved in the development of autosomal recessive osteopetrosis (ARO) in recent genetic studies. However, the molecular mechanism of the disease-related mutations affecting the biological function of SNX10 is unclear. Here, we report the crystal structure of human SNX10 to 2.6 Å resolution. The...

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Source

Identifiers

PMID: 25212774
DOI: 10.1002/prot.24689

Genes

SNX10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis.PMID 25212774Read ↗

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Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From OsteopetrosisSemantic proximity Read ↗

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