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Article

Association of Low Plasma Transthyretin Concentration With Risk of Heart Failure in the General Population.

JAMA cardiology - 1 Mar 2021

Greve Anders M, Christoffersen Mette, Frikke-Schmidt Ruth, Nordestgaard Børge G, Tybjærg-Hansen Anne

Abstract excerpt

Importance: Several lines of evidence support low plasma transthyretin concentration as an in vivo biomarker of transthyretin tetramer instability, a prerequisite for the development of both wild-type transthyretin cardiac amyloidosis (ATTRwt) and hereditary transthyretin cardiac amyloidosis (ATTRm). Both ATTRm and ATTRwt cardiac amyloidosis may manifest as heart failure (HF). However, whether low plasma...

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Identifiers

PMID: 33237279
DOI: 10.1001/jamacardio.2020.5969
PMCID: PMC7689572

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