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Article

Rbm38 Reduces the Transcription Elongation Defect of the SMEK2 Gene Caused by Splicing Deficiency.

International journal of molecular sciences - 20 Nov 2020

Muraoka Shintaro, Fukumura Kazuhiro, Hayashi Megumi, Kataoka Naoyuki, Mayeda Akila, Kaida Daisuke

Abstract excerpt

Pre-mRNA splicing is an essential mechanism for ensuring integrity of the transcriptome in eukaryotes. Therefore, splicing deficiency might cause a decrease in functional proteins and the production of nonfunctional, aberrant proteins. To prevent the production of such aberrant proteins, eukaryotic cells have several mRNA quality control mechanisms. In addition to the known mechanisms, we previously found that...

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PMID: 33233740
DOI: 10.3390/ijms21228799
PMCID: PMC7699959

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