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Prognostic impact and timing considerations for allogeneic hematopoietic stem cell transplantation in chronic myelomonocytic leukemia

20 Nov 2020

Abstract excerpt

Chronic myelomonocytic leukemia (CMML) is a clonal disorder of aging hematopoietic stem cells characterized by overlapping features of myeloproliferation and myelodysplasia 1 , with a median overall survival (OS) of ≤36 months 1 , 2 . Hypomethylating agents (HMAs) have an overall response rate of about 30–40%; however, these agents are ineffective in altering the natural disease biology due to inability to...

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PMID: 33219206
DOI: 10.1038/s41408-020-00387-y

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