Article
Successful bridge therapy of gilteritinib to cord blood transplantation in relapsed acute myeloid leukemia after bone marrow transplantation.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Apr 2021
Kamitani Iku, Saito Takeshi, Yokoyama Hiroki, Nakano Aya, Ishii Hiroto, Tanoue Susumu, Hattori Daiki, Oshima Sayaka, Ishii Shoko, Gunji Tadahiro, Fukushima Ryoko, Katsube Atsushi, Shimada Takaki, Nishiwaki Kaichi, Dobashi Nobuaki, Yano Shingo
Abstract excerpt
The FMS-related tyrosine kinase 3 (FLT3) internal tandem duplication mutations (FLT3-ITD) positive acute myeloid leukemia (AML) is a disease with a dismal outcome. Gilteritinib is a second-generation FLT3 inhibitor with activity against ITD and high affinity toward the FLT3 receptor, thereby showing therapeutic potential for relapsed/refractory FLT3-mutated AML. Bone marrow transplantation (BMT) from a human...
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