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Gilteritinib enhances graft-versus-leukemia effects against FLT3-ITD mutant leukemia after allogeneic hematopoietic stem cell transplantation.

Bone marrow transplantation - 1 May 2022

Zhang Zixuan, Hasegawa Yuta, Hashimoto Daigo, Senjo Hajime, Kikuchi Ryo, Chen Xuanzhong, Yoneda Kazuki, Sekiguchi Tomoko, Kawase Tatsuya, Tsuzuki Hirofumi, Ishio Takashi, Ara Takahide, Ohigashi Hiroyuki, Nakagawa Masao, Teshima Takanori

Abstract excerpt

Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a potentially curative therapy for FLT3 internal tandem duplication mutant (FLT3-ITD+) acute myeloid leukemia, but relapse rate is high. A recent study showed that sorafenib, a first generation FLT3 and multikinase inhibitor, enhanced graft-versus-leukemia (GVL) effects against FLT3-ITD+ leukemia via interleukin-15 (IL-15) production. However, it...

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PMID: 35228711
DOI: 10.1038/s41409-022-01619-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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