Article
Segregation Analysis of Rare NRP1 and NRP2 Variants in Families with Lymphedema.
Genes - 17 Nov 2020
Michelini Sandro, Amato Bruno, Ricci Maurizio, Kenanoglu Sercan, Veselenyiova Dominika, Kurti Danjela, Baglivo Mirko, Manara Elena, Dundar Munis, Krajcovic Juraj, Basha Syed Hussain, Priya Sasi, Serrani Roberta, Miggiano Giacinto A D, Aquilanti Barbara, Matera Giuseppina, Velluti Valeria, Gagliardi Lucilla, Dautaj Astrit, Bertelli Matteo
Abstract excerpt
Neuropilins are transmembrane coreceptors expressed by endothelial cells and neurons. NRP1 and NRP2 bind a variety of ligands, by which they trigger cell signaling, and are important in the development of lymphatic valves and lymphatic capillaries, respectively. This study focuses on identifying rare variants in the NRP1 and NRP2 genes that could be linked to the development of lymphatic malformations in patients...
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