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Article

A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy.

Cell reports. Medicine - 20 Oct 2020

Liu Jian, Campagna Jesus, John Varghese, Damoiseaux Robert, Mokhonova Ekaterina, Becerra Diana, Meng Huan, McNally Elizabeth M, Pyle April D, Kramerova Irina, Spencer Melissa J

Abstract excerpt

Mutations in CAPN3 cause limb girdle muscular dystrophy R1 (LGMDR1, formerly LGMD2A) and lead to progressive and debilitating muscle wasting. Calpain 3 deficiency is associated with impaired CaMKIIβ signaling and blunted transcriptional programs that encode the slow-oxidative muscle phenotype. We conducted a high-throughput screen on a target of CaMKII (Myl2) to identify compounds to override this signaling...

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Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscular Dystrophies, Limb-Girdle

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Source

Open in PubMed Open full text

Identifiers

PMID: 33205074
DOI: 10.1016/j.xcrm.2020.100122
PMCID: PMC7659555

Genes

CAPN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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