Article
Analysis of the interaction effect of 48 SNPs and obesity on type 2 diabetes in Chinese Hans.
BMJ open diabetes research & care - 1 Nov 2020
Liu Jia, Wang Lu, Qian Yun, Shen Qian, Chen Hai, Ma Hongxia, Dai Juncheng, Shen Chong, Jin Guangfu, Hu Zhibin, Shen Hongbing
Abstract excerpt
INTRODUCTION: Both environmental and genetic factors contribute to type 2 diabetes (T2D) risk. Dozens of T2D susceptibility loci have been identified by genome-wide association study. However, these loci account for only a small fraction of the familial T2D risk. We hypothesized that the gene-obesity interaction may contribute to the missing heritability. RESEARCH DESIGN AND METHOD: Forty-eight T2D-associated...
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