Article
APOE Genotype Disclosure and Lifestyle Advice in a Randomized Intervention Study with Finnish Participants.
The Journal of nutrition - 4 Jan 2021
Leskinen Heidi M, Tringham Maaria, Karjalainen Heli, Iso-Touru Terhi K, Hietaranta-Luoma Hanna-Leena, Marnila Pertti J, Pihlava Juha-Matti, Hurme Timo, Kankaanpää Santeri J, Puolijoki Hannu, Åkerman Kari, Tanner Laura, Sandell Mari, Vähäkangas Kirsi, Hopia Anu, Tahvonen Raija, Rokka L Susanna
Abstract excerpt
BACKGROUND: The APOE ε4 allele is associated with higher risks of cardiovascular diseases and Alzheimer disease than ε3 and ε2. OBJECTIVES: We studied the effectiveness of dietary and lifestyle guidance and personal genetic risk information [ε4 carrier (ε4+); ε4 noncarrier (ε4-)] as motivators for a healthier lifestyle. METHODS: A total of 188 healthy Finnish volunteers (82.4% women; mean ± SD age: 51.0 ± 5.6 y;...
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