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Withaferin A activates TRIM16 for its anti-cancer activity in melanoma

12 Nov 2020

Abstract excerpt

Although selective BRAF inhibitors and novel immunotherapies have improved short-term treatment responses in metastatic melanoma patients, acquired resistance to these therapeutics still represent a major challenge in clinical practice. In this study, we evaluated the efficacy of Withaferin A (WFA), derived from the medicinal plant Withania Somnifera, as a novel therapeutic agent for the treatment of melanoma....

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PMID: 33184347
DOI: 10.1038/s41598-020-76722-x

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