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Article

Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences.

Cell death & disease - 20 Apr 2017

Yu Yue, Katiyar Shashank P, Sundar Durai, Kaul Zeenia, Miyako Eijiro, Zhang Zhenya, Kaul Sunil C, Reddel Roger R, Wadhwa Renu

Abstract excerpt

Maintenance of telomere length is the most consistent attribute of cancer cells. Tightly connected to their capacity to overcome replicative mortality, it is achieved either by activation of telomerase or an Alternative mechanism of Lengthening of Telomeres (ALT). Disruption of either of these mechanisms has been shown to induce DNA damage signalling leading to senescence or apoptosis. Telomerase inhibitors are...

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Identifiers

PMID: 28425984
DOI: 10.1038/cddis.2017.33
PMCID: PMC5477593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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