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Article

Quantitative Structure-Mutation-Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction.

BMC bioinformatics - 12 Nov 2020

Huang Liang-Chin, Yeung Wayland, Wang Ye, Cheng Huimin, Venkat Aarya, Li Sheng, Ma Ping, Rasheed Khaled, Kannan Natarajan

Abstract excerpt

BACKGROUND: Protein kinases are a large family of druggable proteins that are genomically and proteomically altered in many human cancers. Kinase-targeted drugs are emerging as promising avenues for personalized medicine because of the differential response shown by altered kinases to drug treatment in patients and cell-based assays. However, an incomplete understanding of the relationships connecting genome,...

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PMID: 33183223
DOI: 10.1186/s12859-020-03842-6
PMCID: PMC7664030

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