Article
Naturally-occurring myopia and loss of cone function in a sheep model of achromatopsia.
Scientific reports - 9 Nov 2020
Ross Maya, Ofri Ron, Aizenberg Itzhak, Abu-Siam Mazen, Pe'er Oren, Arad Dikla, Rosov Alexander, Gootwine Elisha, Dvir Hay, Honig Hen, Obolensky Alexey, Averbukh Edward, Banin Eyal, Gantz Liat
Abstract excerpt
Achromatopsia is an inherited retinal disease characterized by loss of cone photoreceptor function. Day blind CNGA3 mutant Improved Awassi sheep provide a large animal model for achromatopsia. This study measured refractive error and axial length parameters of the eye in this model and evaluated chromatic pupillary light reflex (cPLR) testing as a potential screening test for loss of cone function. Twenty-one...
Topics
- Animals
- Color Vision Defects
- Cyclic Nucleotide-Gated Cation Channels
- Disease Models, Animal
- Electroretinography
- Female
- Light
- Male
- Mutation
- Myopia