Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Flicker cone function in normal and day blind sheep: a large animal model for human achromatopsia caused by CNGA3 mutation.

Documenta ophthalmologica. Advances in ophthalmology - 1 Dec 2014

Ezra-Elia Raaya, Banin Eyal, Honig Hen, Rosov Alexander, Obolensky Alexey, Averbukh Edward, Hauswirth William W, Gootwine Elisha, Ofri Ron

Abstract excerpt

PURPOSE: Recently we reported on day blindness in sheep caused by a mutation in the CNGA3 gene, thus making affected sheep a naturally occurring large animal model for therapeutic intervention in CNGA3 achromatopsia patients. The purpose of this study was to characterize flicker cone function in normal and day blind sheep, with the aim of generating a normative data base for ongoing gene therapy studies. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Ocular
Share to Color Vision Defects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic Nucleotide-Gated Cation Channels

Share to Electroretinography

Share to Photic Stimulation

Share to Retinal Cone Photoreceptor Cells

Share to Sheep Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 25204753
DOI: 10.1007/s10633-014-9458-6
PMCID: PMC4452202

Genes

CNGA3
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Flicker cone function in normal and day blind sheep: a large animal model for human achromatopsia caused by CNGA3 mutation.PMID 25204753Read ↗

Six Years and Counting: Restoration of Photopic Retinal Function and Visual Behavior Following Gene Augmentation Therapy in a Sheep Model of <i>CNGA3</i> AchromatopsiaSemantic proximity Read ↗

Naturally-occurring myopia and loss of cone function in a sheep model of achromatopsia.Semantic proximity Read ↗

Safety and Efficacy Evaluation of rAAV2tYF-PR1.7-hCNGA3 Vector Delivered by Subretinal Injection in CNGA3 Mutant Achromatopsia SheepSemantic proximity Read ↗

Gene Augmentation Therapy for a Missense Substitution in the cGMP-Binding Domain of Ovine CNGA3 Gene Restores Vision in Day-Blind Sheep.Semantic proximity Read ↗

Achromatopsia: Genetics and Gene Therapy.Semantic proximity Read ↗

<i>CNGB3</i>Achromatopsia with Progressive Loss of Residual Cone Function and Impaired Rod-Mediated FunctionSemantic proximity Read ↗

AAV-mediated cone rescue in a naturally occurring mouse model of CNGA3-achromatopsia.Semantic proximity Read ↗

A mutation in gene CNGA3 is associated with day blindness in sheep.Semantic proximity Read ↗

Gene Therapy for Achromatopsia.Semantic proximity Read ↗

Achromatopsia in three sibling Labrador Retrievers in the UK.Semantic proximity Read ↗

Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3.Semantic proximity Read ↗

Gene therapy rescues cone function in congenital achromatopsiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.