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Article

Resistance-Guided Discovery of Elfamycin Antibiotic Producers with Antigonococcal Activity

7 Nov 2020

Abstract excerpt

The rise of bacterial antibiotic resistance coupled with a diminished antibiotic drug pipeline underlines the importance of developing rational strategies to discover new antimicrobials. Microbially derived natural products are the basis for most of the antibiotic arsenal available to modern medicine. Here, we demonstrate a resistance-based approach to identify producers of elfamycins, an under-explored class of...

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PMID: 33164482
DOI: 10.1021/acsinfecdis.0c00467

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