Article
Simplified phenotyping of CYP2D6 for tamoxifen treatment using the N-desmethyl-tamoxifen/ endoxifen ratio.
Breast (Edinburgh, Scotland) - 1 Dec 2020
Lee Clara Inkyung, Low Siew Kee, Maldonado Ricardo, Fox Peter, Balakrishnar Bavanthi, Coulter Sally, de Bruijn Peter, Koolen Stijn L W, Gao Bo, Lynch Jodi, Zdenkowski Nicholas, Hui Rina, Liddle Christopher, Mathijssen Ron H J, Wilcken Nicholas, Wong Mark, Gurney Howard
Abstract excerpt
INTRODUCTION: CYP2D6 protein activity can be inferred from the ratio of N-desmethyl-tamoxifen (NDMT) to endoxifen (E). CYP2D6 polymorphisms are common and can affect CYP2D6 protein activity and E level. Some retrospective studies indicate that E < 16 nM may relate to worse outcome. MATERIALS AND METHODS: A target NDMT/E ratio was defined as associated with an E level of 15 nM in the 161 patient Test cohort of...
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