Article
Phlebotomus perniciosus Recombinant Salivary Proteins Polarize Murine Macrophages Toward the Anti-Inflammatory Phenotype.
Frontiers in cellular and infection microbiology - 1 Jan 2020
Sumova Petra, Polanska Nikola, Lestinova Tereza, Spitzova Tatiana, Kalouskova Barbora, Vanek Ondrej, Volf Petr, Rohousova Iva
Abstract excerpt
Phlebotomus perniciosus (Diptera: Phlebotominae) is a medically and veterinary important insect vector. It transmits the unicellular parasite Leishmania infantum that multiplies intracellularly in macrophages causing life-threatening visceral diseases. Leishmania establishment in the vertebrate host is substantially influenced by immunomodulatory properties of vector saliva that are obligatorily co-injected into...
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