Diagnostic Utility of a Custom 34-Gene Anchored Multiplex PCR-Based Next-Generation Sequencing Fusion Panel for the Diagnosis of Bone and Soft Tissue Neoplasms With Identification of Novel USP6 Fusion Partners in Aneurysmal Bone Cysts.

doi:10.5858/arpa.2020-0336-OA

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Diagnostic Utility of a Custom 34-Gene Anchored Multiplex PCR-Based Next-Generation Sequencing Fusion Panel for the Diagnosis of Bone and Soft Tissue Neoplasms With Identification of Novel USP6 Fusion Partners in Aneurysmal Bone Cysts.

Archives of pathology & laboratory medicine - 1 Jul 2021

Dermawan Josephine K, Cheng Yu Wei, Tu Zheng Jin, Meyer Anders, Habeeb Omar, Zou Youran, Goldblum John R, Billings Steven D, Kilpatrick Scott E, Reith John D, Shurtleff Sheila A, Farkas Daniel H, Rubin Brian P, Azzato Elizabeth M

Abstract excerpt

CONTEXT.—: Bone and soft tissue tumors are heterogeneous, diagnostically challenging, and often defined by gene fusions. OBJECTIVE.—: To present our experience using a custom 34-gene targeted sequencing fusion panel. DESIGN.—: Total nucleic acid extracted from formalin-fixed, paraffin-embedded (FFPE) tumor specimens was subjected to open-ended, nested anchored multiplex polymerase chain reaction and enrichment of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diagnosis, Differential

Share to Gene Fusion

Share to Multiplex Polymerase Chain Reaction

Share to Predictive Value of Tests

Share to Soft Tissue Neoplasms

Share to Transcriptome

Share to Ubiquitin Thiolesterase

Source

Open in PubMed

Identifiers

PMID: 33147323
DOI: 10.5858/arpa.2020-0336-OA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diagnostic Utility of a Custom 34-Gene Anchored Multiplex PCR-Based Next-Generation Sequencing Fusion Panel for the Diagnosis of Bone and Soft Tissue Neoplasms With Identification of Novel USP6 Fusion Partners in Aneurysmal Bone Cysts.PMID 33147323Read ↗

Novel ASAP1‐USP6, FAT1‐USP6, SAR1A‐USP6, and TNC‐USP6 fusions in primary aneurysmal bone cystSemantic proximity Read ↗

Novel and unusual USP6 fusion partners in aneurysmal bone cyst and their role in pathogenesis and histopathological evaluation of this diseaseSemantic proximity Read ↗

Detecting disease‐defining gene fusions in unclassified round cell sarcomas using anchored multiplex PCR/targeted RNA next‐generation sequencing—Molecular and clinicopathological characterization of 16 casesSemantic proximity Read ↗

Development and Evaluation of a Pan-Sarcoma Fusion Gene Detection Assay Using the NanoString nCounter PlatformSemantic proximity Read ↗

Role of Next-Generation Sequencing as a Diagnostic Tool for the Evaluation of Bone and Soft-Tissue Tumors.Semantic proximity Read ↗

Establishing an RNA fusions panel in soft tissue sarcoma with clinical validationSemantic proximity Read ↗

Development and validation of an RNA sequencing panel for gene fusions in soft tissue sarcomaSemantic proximity Read ↗

RNA sequencing identifies a novel USP9X‐USP6 promoter swap gene fusion in a primary aneurysmal bone cystSemantic proximity Read ↗

Gene Fusion Identification Using Anchor-Based Multiplex PCR and Next-Generation SequencingSemantic proximity Read ↗

Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.Semantic proximity Read ↗

An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencingSemantic proximity Read ↗

Recurrent and novel fusions detected by targeted RNA sequencing as part of the diagnostic workflow of soft tissue and bone tumoursSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.