Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome editing of CCR5 by CRISPR-Cas9 in Mauritian cynomolgus macaque embryos

28 Oct 2020

Abstract excerpt

The discovery that CCR5 serves as an R5-HIV-1 co-receptor, coupled with findings of protection from HIV infection in individuals lacking CCR5, led to the exploration of novel therapeutic strategies for HIV infection based on genome editing of CCR5. Advancing translation of CCR5-mutant-based cellular therapies for HIV requires development of novel physiologically relevant animal models. Mauritian cynomolgus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to HIV Research and Treatment
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33116147
DOI: 10.1038/s41598-020-75295-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome editing of CCR5 by CRISPR-Cas9 in Mauritian cynomolgus macaque embryosPMID 33116147Read ↗

CCR5-Δ32 biology, gene editing, and warnings for the future of CRISPR-Cas9 as a human and humane gene editing toolSemantic proximity Read ↗

Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus InfectionSemantic proximity Read ↗

Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infectionSemantic proximity Read ↗

Antiretrovirals to CCR5 CRISPR/Cas9 gene editing - A paradigm shift chasing an HIV cureSemantic proximity Read ↗

Generation of SIV resistant T cells and Macrophages from Nonhuman Primate Induced Pluripotent Stem Cells with Edited CCR5 locusSemantic proximity Read ↗

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates.Semantic proximity Read ↗

Gene-edited babies: What went wrong and what could go wrongSemantic proximity Read ↗

Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vectorSemantic proximity Read ↗

TRIM5α polymorphism identification in cynomolgus macaques of Vietnamese origin and Chinese rhesus macaques.Semantic proximity Read ↗

Efficient marmoset genome engineering by autologous embryo transfer and CRISPR/Cas9 technology.Semantic proximity Read ↗

Efficient modification of <i>CCR5</i> in primary human hematopoietic cells using a megaTAL nuclease and AAV donor templateSemantic proximity Read ↗

TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent mannerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.