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Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection

27 Oct 2020

Abstract excerpt

In most of the world, Dengue virus (DENV) is mainly transmitted by the mosquito Aedes aegypti while in Europe, Aedes albopictus is responsible for human DENV cases since 2010. Identifying mutations that make DENV more competent for transmission by Ae. albopictus will help to predict emergence of epidemic strains. Ten serial passages in vivo in Ae. albopictus led to select DENV-1 strains with greater infectivity...

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PMID: 33110109
DOI: 10.1038/s41598-020-75042-4

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