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Article

A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice.

Scientific reports - 27 Oct 2020

Ihara Kensuke, Sasano Tetsuo, Hiraoka Yuichi, Togo-Ohno Marina, Soejima Yurie, Sawabe Motoji, Tsuchiya Megumi, Ogawa Hidesato, Furukawa Tetsushi, Kuroyanagi Hidehito

Abstract excerpt

Dilated cardiomyopathy (DCM) is a fatal heart disease characterized by left ventricular dilatation and cardiac dysfunction. Recent genetic studies on DCM have identified causative mutations in over 60 genes, including RBM20, which encodes a regulator of heart-specific splicing. DCM patients with RBM20 mutations have been reported to present with more severe cardiac phenotypes, including impaired cardiac function,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33110103
DOI: 10.1038/s41598-020-74800-8
PMCID: PMC7591520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice.PMID 33110103Read ↗

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