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Generation of an induced pluripotent stem cell (iPSC) line (THSJTUi001-A) from a Wilson's disease patient harboring a homozygous Arg778Leu mutation in ATP7B gene.

Stem cell research - 1 Dec 2020

Wang Shu-Hong, Wang Xiao-Ping

Abstract excerpt

Induced pluripotent stem cell (iPSC) line, THSJTUi001-A, was generated from a 26-year-old Chinese male patient with Wilson's disease carrying a homozygous Arg778Leu mutation in ATP7B gene, using non-integrated episomal reprogramming vectors. This cell line had normal karyotype, expressed pluripotency markers and could differentiate into the three germ layers in vivo.

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Cell Line
Hepatolenticular Degeneration
Homozygote
Induced Pluripotent Stem Cells
Mutation

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PMID: 33096383
DOI: 10.1016/j.scr.2020.102050

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Generation of an induced pluripotent stem cell (iPSC) line (THSJTUi001-A) from a Wilson's disease patient harboring a homozygous Arg778Leu mutation in ATP7B gene.PMID 33096383Read ↗

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