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Article

DNA Methylation at Birth Predicts Intellectual Functioning and Autism Features in Children with Fragile X Syndrome.

International journal of molecular sciences - 19 Oct 2020

Kraan Claudine M, Baker Emma K, Arpone Marta, Bui Minh, Ling Ling, Gamage Dinusha, Bretherton Lesley, Rogers Carolyn, Field Michael J, Wotton Tiffany L, Francis David, Hunter Matt F, Cohen Jonathan, Amor David J, Godler David E

Abstract excerpt

Fragile X syndrome (FXS) is a leading single-gene cause of intellectual disability (ID) with autism features. This study analysed diagnostic and prognostic utility of the Fragile X-Related Epigenetic Element 2 DNA methylation (FREE2m) assessed by Methylation Specific-Quantitative Melt Analysis and the EpiTYPER system, in retrospectively retrieved newborn blood spots (NBS) and newly created dried blood spots (DBS)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epigenesis, Genetic

Share to Fragile X Mental Retardation Protein

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Share to Infant, Newborn

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Identifiers

PMID: 33086711
DOI: 10.3390/ijms21207735
PMCID: PMC7589848

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