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Visualization of uracils created by APOBEC3A using UdgX shows colocalization with RPA at stalled replication forks

18 Sept 2020

Abstract excerpt

The AID/APOBEC enzymes deaminate cytosines in single-stranded DNA (ssDNA) and play key roles in innate and adaptive immunity. The resulting uracils cause mutations and strand breaks that inactivate viruses and diversify antibody repertoire. Mutational evidence suggests that two members of this family, APOBEC3A (A3A) and APOBEC3B, deaminate cytosines in the lagging-strand template during replication. To obtain...

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PMID: 33074285
DOI: 10.1093/nar/gkaa845

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